“High” PEEP is used as part of an Open Lung Approach To Ventilation for Acute Respiratory Distress Syndrome (ARDS).How to optimise PEEP is a controversial topic, but should involve (1) optimisation of oxygenation and (2) minimisation of ventilator induced lung injury (VILI), and should should be individualised for a given patient.PEEP is routinely used in mechanical ventilation to prevent collapse of distal alveoli, and to promote recruitment of collapsed alveoli.PEEP acts to distend distal alveoli, assuming there is no airway obstruction. Positive End-Expiratory Pressure (PEEP) is the maintenance of positive pressure (above atmospheric) at the airway opening at the end of expiration.
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